![]() The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion Defines the range of the hosts and specificity of the virus Main component to bind with the neutralizing antibody Key target for vaccine design Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. S2 contains basic elements needed for the membrane fusion. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike is essential for both host specificity and viral infectivity. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2 DPP4, dipeptidyl peptidase-4 APN, aminopeptidase N CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1 Sia, sialic acid O-ac Sia, O-acetylated sialic acid. The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Special Offer: Custom Recombinant Antibody Production Service.Order before September 15th 2022 and get a voucher up to 750€.Producing Challenging Proteins in the Golden Age of Protein Engineering. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |